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Epithalon is a synthetic tetrapeptide with the amino-acid sequence alanyl-glutamyl-aspartyl-glycine. It belongs to the short synthetic peptide class and was developed as a synthetic analogue of a pineal peptide preparation.
In the published preclinical literature, Epithalon has been characterised at the molecular level for its sequence-specific binding to short DNA oligonucleotides and, in cultured cell and animal-cell models, for its association with telomerase enzyme activity and with gene-expression markers measured by molecular-biology methods. It is supplied as a research compound and is not intended for human or veterinary use.
Epithalon has been characterised in preclinical laboratory models. The primary studies below, in a cell line with isolated DNA and in a bovine cell model, examined molecular and cellular endpoints, with the work centred on the tetrapeptide’s sequence-specific DNA binding and on telomerase enzyme activity assayed in culture. The literature is preclinical; it describes the compound, not any outcome in humans.
In vitro
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
Using fluorescence-quenching constants on isolated deoxyribooligonucleotides and DNA, the study measured the sequence-specific binding of the tetrapeptide Ala-Glu-Asp-Gly, reporting a preference for CNG and CAG-containing sequences and a sensitivity to cytosine methylation status, alongside nuclear penetration assayed in a HeLa cell line.
Read the study ↗
Animal cell model
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
In a bovine in-vitro oocyte and embryo-culture model, the study assayed telomerase protein level and localisation by immunofluorescence and measured gene expression by quantitative PCR, reactive-oxygen-species level, and mitochondrial membrane potential as molecular endpoints of the peptide’s effect on telomerase activity.
Read the study ↗
Full documentation, on the record. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.
Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product.
