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Testagen

20mg lyophilised · research peptide
$50  USD USD / vial
In stock, ships Mon to Fri
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📄 Certificate of Analysis available on request

20mg lyophilised · research peptide
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🇺🇸Made in the USASynthesised domestically
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About this compound

Testagen is a synthetic short-peptide bioregulator from the Khavinson family of low-molecular-weight regulatory peptides, the same structural class as Epithalon and Pinealon. It is a short chain of amino-acid residues rather than a protein, supplied as a defined synthetic compound.

In the published preclinical literature, Testagen has been characterised at the molecular level for how a short peptide of this class is taken up by cultured cells and how it associates, in cell-free assays, with deoxyribonucleotides, DNA, and histone-DNA complexes, alongside animal-model work recording endocrine-tissue endpoints. It is supplied as a research compound and is not intended for human or veterinary use.

Form
Lyophilised powder, supplied as 20mg per vial.
Vial size
20mg per vial.
CAS
1026993-38-3
Storage
Store the sealed lyophilised vial at -20°C, away from direct sunlight and protected from light.
Shelf life
The lyophilised form has a shelf life of up to 24 months when stored as directed.
Handling
Handle in accordance with standard laboratory safety practice. A Certificate of Analysis and a Safety Data Sheet are available on request.
Intended use
For research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures.

Research

Testagen has been characterised in preclinical laboratory models. The primary studies below, in cultured cells, cell-free binding assays, and an animal endocrine model, recorded uptake, binding, and tissue-level endpoints, with the work centred on how a short peptide of this class is handled by cells and how it associates with DNA and histones. The literature is thin and preclinical; it describes the compound, not any outcome in humans.

Cell uptake and DNA binding


In vitro
Penetration of short fluorescence-labelled peptides into the nucleus in HeLa cells and in-vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
Fedoreyeva et al. · 2011 · Biochemistry (Moscow)
In cultured HeLa cells, the localisation of FITC-labelled Lys-Glu-Asp-Gly (named in the report as testagen) was tracked into the cytoplasm, nucleus, and nucleolus, and in cell-free assays fluorescence quenching was used to measure the peptide’s binding to deoxyribooligonucleotides and DNA as the recorded interaction endpoints.
Read the study ↗


In vitro
Interaction of short peptides with FITC-labelled wheat histones and their complexes with deoxyribooligonucleotides
Fedoreyeva et al. · 2013 · Biochemistry (Moscow)
In cell-free assays, fluorescence quenching was used to measure the binding of six short peptides, Lys-Glu-Asp-Gly included by sequence, to FITC-labelled wheat histones and to histone-deoxyribooligonucleotide complexes, mapping the association with the N-terminal histone regions as the measured endpoint.
Read the study ↗

Animal endocrine model


Animal model
Effects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomised young chickens and old hens
Kuznik et al. · 2011 · Bulletin of Experimental Biology and Medicine
In a hypophysectomised chicken and hen model, Lys-Glu-Asp-Gly and a comparator tetrapeptide were administered over a 40-day course and thyrotropic-hormone and thyroid-hormone concentrations, together with thyroid-gland structure, were measured as the recorded endpoints across the two age groups.
Read the study ↗

Full documentation, on the record. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.

Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product.

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